Q: how to open a new buffer and save it?

C-x b

C-h v load-path ;;To see which directories are in your load-path, type 
C-x-o           ;;REMOVE following blank lines
C-x o           ;; switch between windows
C-d
M-d
M-<del>
M-5 C-n         ;;go down five lines
C-x ->          ;;go to next buffer
C-x C-w         ;; save as
M-g-g line_num  ;; go to line xx

view-echo-area-messages  shows all the startup info
uncomment-region + comment-region

M-x global-set-key

:-) I can attach ''Cltr+m'' to "moinmoin-mode"

- muse_command - keymaps

http://www.gnu.org/software/emacs/emacs-lisp-intro/html_mono/emacs-lisp-intro.html#Keymaps

check this link to know how to set globle key and mode-specific keys

set a keyboard macro is so esay and yet powerful, I can bind it to a

command and a keyboard short cut afterwards.

http://www.gnu.org/software/emacs/manual/html_node/emacs/Save-Keyboard-Macro.html#Save-Keyboard-Macro

Q :now i need to know how to save these setting permanently?

A: M-x insert-kbd-macro <RET> macroname <RET>

and save the out put to .emacs

http://www.gnu.org/software/emacs/manual/html_node/emacs/Save-Keyboard-Macro.html#Save-Keyboard-Macro

Q: How to kill a region ?

A: C-space to set a "mark", then go to any point, C-w to kill the region between current point and the "mark"

nice doc goes here http://www.cs.utah.edu/dept/old/texinfo/emacs18/emacs_13.html